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Therapeutic Antibody Engineering: Current and Future Advances Driving the Strongest Growth Area in the Pharmaceutical Industry (Woodhead Publishing Series in Biomedicine)

Amazon.com Price: $271.46 (as of 12/05/2019 16:48 PST- Details)

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The field of antibody engineering has turn into an important and integral a part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that more than a few genetic engineering approaches will have on future candidates. Chapters in the first a part of the book provide an introduction to monoclonal antibodies, their discovery and development and the fundamental technologies used in their production. Following chapters cover a variety of specific issues when it comes to different aspects of antibody engineering, including variable chain engineering, targets and mechanisms of action, classes of antibody and using antibody fragments, among many other topics. The last a part of the book examines development issues, the interaction of human IgGs with non-human systems, and cell line development, before a conclusion having a look at future issues affecting the field of therapeutic antibody engineering.

Goes beyond the usual engineering issues covered by most books and delves into structure-function relationships
Integration of knowledge across all areas of antibody engineering, development, and marketing
Discusses how current and future genetic engineering of cell lines will pave the best way for much higher productivity

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